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The oral daily dose far exceeds the vitamin requirement because the normal transporter protein-mediated absorption is absent, leaving only very inefficient intestinal passive absorption
In cells, this vitamin functions as a cofactor for two vital enzymatic reactions: (1) methionine synthase, i.e
Cobalamin separates from the protein during digestion, and a substance called intrinsic factor binds to cobalamin for the body to absorb it into the blood
Conditions such as pernicious anemia, which affects the absorption of B12, may also warrant coverage, as well as certain chemotherapy treatments that necessitate B12 supplementation
That sensation usually indicates needle contact with a nerve
